Cyclooxygenase-2 polymorphism: putting a brake on the inflammatory response to vascular injury?
نویسندگان
چکیده
Prostaglandin endoperoxide H synthase (PGHS) catalyzes the conversion of arachidonic acid to PGH2, the first committed step in the biosynthesis of a range of lipid mediators, termed prostaglandins (PGs) and thromboxanes.1 PGHS has both cyclooxygenase (COX) and hydroperoxidase activities.2 Aspirin and a variety of nonsteroidal antiinflammatory drugs (NSAIDs) inhibit the COX activity of PGHS3 (Figure 1).
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ورودعنوان ژورنال:
- Arteriosclerosis, thrombosis, and vascular biology
دوره 22 10 شماره
صفحات -
تاریخ انتشار 2002